Предиктивная и прогностическая значимость явления потери гетерозиготности в генах ABC-транспортеров в опухоли молочной железы

ABC-transporter family genes have been well studied and their involvement in the development of drug resistance has been assessed. The presence of aberrant conditions in these genes can affect the treatment and prognosis of the disease. Loss of heterozygosity (LOH) is one of these conditions; it is a common event in cancer development. Therefore, the aim of this study was to investigate the relationship between LOH in ABC transporter genes in breast cancer and response to chemotherapy and disease prognosis. Material and Methods. A total of 130 breast cancer patients were included in the study. Microarray analysis was performed on Affymetrix CytoScan™ HD Array high-density DNA chips to assess LOH status. Chromosome Analysis Suite 4.1 software (Affymetrix, USA) was used to process microarray results. Results. Forty-nine ABC transporter genes were evaluated for LOH. The frequency of LOH ranged from 6.9 % to 90 %. An association analysis identified two genes: ABCG5 and ABCG8, in which the presence of LOH was associated with a lack of objective response to neoadjuvant chemotherapy. The presence of LOH in the ABCA5, ABCA6, ABCA8, ABCA9, ABCA10 and ABCC3 genes was associated with high rates of metastasis-free survival (log-rank test, p<0.04). conclusion. The presence of loss of heterozygosity in the ABC transporter genes was found to have no significant effect on the response to chemotherapy. However, a high prognostic potential of ABCA family genes was found

Some problems and prospects of the nephrology center

The problem of supportability of the population with renal replacement therapy is one of the key problems in the modern healthcare system. The quality of medical care in general depends on its solution. In recent years, positive trends have been observed in the activities of the domestic renal replacement therapy service, but these changes are not enough to meet the needs of the population adequately.Проблема обеспеченности населения заместительной почечной терапией является одной из ключевых в современной системе здравоохранения. от ее решения зависит качество оказания медицинской помощи в целом. В деятельности отечественной службы заместительной почечной терапии в последние годы прослеживаются положительные тенденции, однако этих изменений явно недостаточно для адекватного покрытия потребности населения

The impact of social factors on the biological adaptation processes in children with mental retardation of psychogenic origin

The research is devoted to the study of biological adaptation of 6-7 year old children with mental retardation. We observed 187 children, including children with mental retardation into the main group (91 persons). Children whose mental development corresponded to their age were included into the control group (96 persons). It was found that children with mental retardation have some peculiarities in the course of processes of biological adaptation. They are characterized by the original functional tension of the cardiovascular system, by the predominance of sympathetic regulation pattern, a high index of strain (1.6 times higher than that of children whose mental development corresponds to their age), and by the index of functional changes. We revealed significant differences in the values of the index of functional changes at rest and after clinic orthostatic test in children with mental retardation of different origin. We noticed direct correlation between high levels of stress of regulatory systems in children with mental retardation on the one hand, and structural, psychological deformation of the family (r = 1,00), and living conditions (r = 0,76) on the other hand.Исследование посвящено изучению биологической адаптации детей 6-7 лет с задержкой психического развития. Под наблюдением находилось 187 детей, из них дети с задержкой психического развития составили основную группу (91 человек) и дети, чье психическое развитие соответствует возрасту - группа контроля - 96 человек. Установлено, что дети с ЗПР имеют некоторые особенности в течении процессов биологической адаптации, которые характеризуются изначальным функциональным напряжением со стороны сердечно-сосудистой системы, преобладанием симпатического контура регуляции, высоким индексом напряжения (в 1,6 раза выше, чем у детей чье психическое развитие соответствует возрасту) и индексом функциональных изменений. Выявлены достоверные различия в значениях индекса функциональных изменений как в состоянии покоя, так и после выполнения КОП у детей с задержкой психического развития различного происхождения. Установлена прямая корреляционная связь между высоким уровнем напряжения регуляторных систем организма детей с задержкой психического развития и структурной, психологической деформацией семьи (г=1,00), жилищно-бытовые условиями (г=0,76)

Modern problems of teaching human anatomy in medical universities and prospects for their solution

Teaching anatomy in medical schools requires reforming in order to improve the quality of teaching students at the current stage of training qualified doctors.Преподавание анатомии в медицинских вузах требует реформирования с целью улучшения качества обучения студентов на современном этапе подготовки квалифицированных врачей

Предиктивная и прогностическая значимость явления потери гетерозиготности в генах ABC-транспортеров в опухоли молочной железы

ABC-transporter family genes have been well studied and their involvement in the development of drug resistance has been assessed. The presence of aberrant conditions in these genes can affect the treatment and prognosis of the disease. Loss of heterozygosity (LOH) is one of these conditions; it is a common event in cancer development. therefore, The aim of this study was to investigate the relationship between LOH in ABC transporter genes in breast cancer and response to chemotherapy and disease prognosis. Material and methods. a total of 130 breast cancer patients were included in the study. microarray analysis was performed on Affymetrix Cytoscantm HD Array high-density DNA chips to assess LOH status. Chromosome Analysis Suite 4.1 software (Affymetrix, USA) was used to process microarray results. Results. Forty-nine ABC transporter genes were evaluated for LOH. the frequency of LOH ranged from 6.9 % to 90 %. an association analysis identified two genes: ABCG5 and ABCG8, in which the presence of LOH was associated with a lack of objective response to neoadjuvant chemotherapy. the presence of LOH in the ABCA5, ABCA6, ABCA8, ABCA9, ABCA10 and ABCC3 genes was associated with high rates of metastasis-free survival (log-rank test, p&lt;0.04). Conclusion. The presence of loss of heterozygosity in the ABC transporter genes was found to have no significant effect on the response to chemotherapy. However, a high prognostic potential of ABCA family genes was found.Гены семейства ABC-транспортеров хорошо изучены, оценено их влияние на формирование лекарственной устойчивости. Показано, что наличие аберрантных состояний в этих генах может влиять на лечение и прогноз заболевания. Одним из таких состояний является потеря гетерозиготности (LOH), которая часто встречается в опухолевых клетках. Цель исследования ‒ изучение связи потери гетерозиготности в генах ABC-транспортеров в опухоли молочной железы с эффектом химиотерапии и прогнозом заболевания. Материал и методы. В исследование было включено 130 больных раком молочной железы. Для оценки статуса LOH был проведен микрочиповый анализ на ДНК-чипах высокой плотности Affymetrix Cytoscantm HD Array. Для обработки результатов микрочипов использовалось программное обеспечение Chromosome Analysis Suite 4.1 (Affymetrix, USA). Результаты. На предмет потери гетерозиготности было оценено 49 генов ABC-транспортеров. Частота LOH варьировала от 6,9 до 90 %. Ассоциативный анализ выявил два гена ABCG5 и ABCG8, наличие потери гетерозиготности в которых было связано с отсутствием объективного ответа на неоадъювантную химиотерапию. Наличие LOH в генах ABCA5, ABCA6, ABCA8, ABCA9, ABCA10 и ABCC3 было связано с более высокими показателями безметастатической выживаемости (log-rank test, p&lt;0,04). Выводы. Было установлено, что наличие потери гетерозиготности в генах ABC-транспортеров не оказывает значительного влияния на эффективность химиотерапии. Однако был показан высокий прогностический потенциал генов семейства ABCA

Measurement of the Dipion Mass Spectrum in X(3872) -> J/Psi Pi+ Pi- Decays

We measure the dipion mass spectrum in X(3872)--> J/Psi Pi+ Pi- decays using 360 pb-1 of pbar-p collisions at 1.96 TeV collected with the CDF II detector. The spectrum is fit with predictions for odd C-parity (3S1, 1P1, and 3DJ) charmonia decaying to J/Psi Pi+ Pi-, as well as even C-parity states in which the pions are from Rho0 decay. The latter case also encompasses exotic interpretations, such as a D0-D*0Bar molecule. Only the 3S1 and J/Psi Rho hypotheses are compatible with our data. Since 3S1 is untenable on other grounds, decay via J/Psi Rho is favored, which implies C=+1 for the X(3872). Models for different J/Psi-Rho angular momenta L are considered. Flexibility in the models, especially the introduction of Rho-Omega interference, enable good descriptions of our data for both L=0 and 1.Comment: 7 pages, 4 figures -- Submitted to Phys. Rev. Let

Search for Higgs Boson Decaying to b-bbar and Produced in Association with W Bosons in p-pbar Collisions at sqrt{s}=1.96 TeV

We present a search for Higgs bosons decaying into b-bbar and produced in association with W bosons in p-pbar collisions at sqrt{s}=1.96 TeV. This search uses 320 pb-1 of the dataset accumulated by the upgraded Collider Detector at Fermilab. Events are selected that have a high-transverse momentum electron or muon, missing transverse energy, and two jets, one of which is consistent with a hadronization of a b quark. Both the number of events and the dijet mass distribution are consistent with standard model background expectations, and we set 95% confidence level upper limits on the production cross section times branching ratio for the Higgs boson or any new particle with similar decay kinematics. These upper limits range from 10 pb for mH=110 GeV/c2 to 3 pb for mH=150 GeV/c2.Comment: 7 pages, 3 figures; updated title to published versio

Measurement of the Inclusive Jet Cross Section in ppbar Interactions at sqrt{s}=1.96 TeV Using a Cone-based Jet Algorithm

We present a measurement of the inclusive jet cross section in ppbar interactions at sqrt{s}=1.96 TeV using 385 pb^{-1} of data collected with the CDF II detector at the Fermilab Tevatron. The results are obtained using an improved cone-based jet algorithm (Midpoint). The data cover the jet transverse momentum range from 61 to 620 GeV/c, extending the reach by almost 150 GeV/c compared with previous measurements at the Tevatron. The results are in good agreement with next-to-leading order perturbative QCD predictions using the CTEQ6.1M parton distribution functions.Comment: 19 pages, 2 figures, 1 tabl

Search for anomalous semileptonic decay of heavy flavor hadrons produced in association with a W boson at CDF II

We present a search for anomalous semileptonic decays of heavy flavor hadrons produced in association with a $W$ boson, in proton-antiproton collisions at sqrt{s}=1.96 TeV. We use 162 pb-1 of data collected with the CDF II detector at the Fermilab Tevatron Collider. We select events with one W boson and at least one jet with an identified secondary vertex. In the jets with a secondary vertex we look for a semileptonic decay to a muon. We compare the number of jets with both a secondary vertex and a semileptonic decay, and the kinematic properties of these jets, with the standard model expectation of W plus heavy flavor production and decay. No discrepancy is seen between the observation and the expectation, and we set limits on the production cross section of a B-like hadron with an anomalously high semileptonic branching ratio.Comment: 8 pages, 2 figures, submitted to PRD-RC; replaced to adjust the page forma

Search for Second-Generation Scalar Leptoquarks in ppˉ\bm{p \bar{p}} Collisions at s\sqrt{s}=1.96 TeV

Results on a search for pair production of second generation scalar leptoquark in $p \bar{p}$ collisions at $\sqrt{s}$=1.96 TeV are reported. The data analyzed were collected by the CDF detector during the 2002-2003 Tevatron Run II and correspond to an integrated luminosity of 198 pb$^{-1}$. Leptoquarks (LQ) are sought through their decay into (charged) leptons and quarks, with final state signatures represented by two muons and jets and one muon, large transverse missing energy and jets. We observe no evidence for $LQ$ production and derive 95% C.L. upper limits on the $LQ$ production cross sections as well as lower limits on their mass as a function of $\beta$, where $\beta$ is the branching fraction for $LQ \to \mu q$.Comment: 9 pages (3 author list) 5 figure